Advances in the treatment of pancreatic neuroendocrine tumours
نویسندگان
چکیده
منابع مشابه
Advances in the treatment of pancreatic neuroendocrine tumours.
Pancreatic neuroendocrine tumours (pNETs) are relatively rare and generally felt to follow an indolent course. But poorly differentiated tumours can behave aggressively with 5-year survival ranging from 31% to 48%. Recent data suggest that patients with pNETs may derive benefit from treatment targeting the molecular changes expressed in this tumour group. This article describes advances in the ...
متن کاملSurgical treatment of pancreatic neuroendocrine tumours - clinical experience.
UNLABELLED The aim of the work was the clinical characteristics and analysis of preliminary results for surgical treatment of pancreatic neuroendocrine tumors (PNETs), based on own material. MATERIAL AND METHODS. In the period from 2005 to 2009, in the Department of Gastrointestinal Surgery, Silesian Medical University in Katowice, there were 27 patients (15 males and 12 females) treated surgic...
متن کاملSomatostatin receptors in gastroentero-pancreatic neuroendocrine tumours.
Five somatostatin receptor (sst) subtype genes, sst(1), sst(2), sst(3), sst(4) and sst(5), have been cloned and characterised. The five sst subtypes all bind natural somatostatin-14 and somatostatin-28 with high affinity. Endocrine pancreatic and endocrine digestive tract tumours also express multiple sst subtypes, but sst(2) predominance is generally found. However, there is considerable varia...
متن کاملWhole-genome landscape of pancreatic neuroendocrine tumours
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to more sensitive detection methods, and this increase is creating challenges for clinical management. We performed whole-genome sequencing of 102 primary PanNETs and defined the genomic events that characterize their pathogenesis. Here we describe the mutational signatures they harbour, including a deficiency in G...
متن کاملRecent advances in the imaging of adrenal and neuroendocrine tumours.
Computed tomography (CT) remains the cornerstone of adrenal imaging. Masses are initially assessed without contrast medium to measure their attenuation value (Hounsfield Unit, HU). About 70% of benign cortical adenomas will contain sufficient intracellular lipid to lower the attenuation value to 10 HU. If the attenuation value is greater than 10 HU, immediate and delayed scans are performed fol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: QJM
سال: 2012
ISSN: 1460-2725,1460-2393
DOI: 10.1093/qjmed/hcs032